TOP > CO2DDS -Story of CO2- > The third ; Mechanism of the cosmetic effect by the carbon dioxide of eCO2GEL Part.1

CO2DDS -Story of CO2-

The third Mechanism of the cosmetic effect by the carbon dioxide of eCO2GEL Part.1

It seems that various carbon dioxide packing agents appear on the market recently, but incorrect information about carbon dioxide packing agents is flowing. Tanaka, C.E.O. of our company, has elaborated the basic idea of an external carbon dioxide agent when he worked for the new medicine research institute of Kanebo where he confirmed the validity of an external carbon dioxide agent in basic experiments, then completed the research after he left Kanebo, and made the present product. In order for you to understand correctly the cosmetics effect (there are medical effects as well) of carbon dioxide, the mechanism of action of carbon dioxide will be explained in more detail.

1. Absorption of Carbon Dioxide thorough Skin

A. Not bubble but molecular carbon dioxide is absorbed through the skin.

We use the term "carbon dioxide gas" for better understanding for non-experts. But in fact, transdermally absorbed carbon dioxide is not in the form of visible bubble but of invisible water-dissolved molecular carbon dioxide. When you open a bottle of cola or beer, you can see vigorous bubbling. You may just think that carbon dioxide bubbles are dissolved in beverages. But in such bottles carbon dioxide is forcibly dissolved under high-pressure. When the bottle is opened, the pressure inside the bottle is decreased and then some part of carbon dioxide escapes from the beverage into the air visible as bubbles.
Cosmetic effects can be obtained by transdermally absorbed invisible molecular carbon dioxide, not by their bubbles. For example, if you blow your skin with carbon dioxide gas from a tube, carbon dioxide can be absorbed little, and no cosmetic effect can be obtained

B. The reason why eCO2GEL has weak acidity

"Carbon Dioxide" tends to dissolve into water easily and a part of it may react with water to generate " carbonic acid = H2CO3 "
It is in the state of the "carbonated water" which is often seen.

CO2+H2O⇔H2CO3 (1)

A part of carbonic acid dissociates to generate " bicarbonate ion = HCO3- " in water.

H2CO3⇔H++HCO3- (2)

The lower the pH of the solution is, the more carbon dioxide exists in molecular state. Then the amount of transdermally absorbed carbon dioxide increases. Conversely, if the pH of the solution is high, carbon dioxide in water changes in carbonic acid and bicarbonate ion which are hardly absorbed through skin. If the solution is alkaline of pH 8, 98% of the dissolved carbon dioxide dissociates to generate ion, then the quantity of molecular carbon dioxide absorbed through skin becomes small, and the cosmetic effect can hardly be expected.

Acidity of the mixture of agent A (granule) and agent B (gel base) of eCO2GEL is about pH6.5, which indicates that more than half of the carbon dioxide dissolved in water of the gel exists as molecular state. If the pH is too low and you have a wound on your skin, the mixture may stimulate the wound as a strong acidic carbonated water. If the pH is lower than 4, carbon dioxide cannot dissolve as molecular state conversely.

A cosmetic method applying a "special cream" to skin in order to absorb oxygen through skin in an oxygen-rich room to activate metabolism was developed in the U.S.A. It is a scientific common sense that oxygen is hardly absorbed through human skin, so it was beaten as a fake business.

As oxygen-related cosmetics, per-fluorocarbon (artificial erythrocyte a a pharmaceutical company, which does not exist now, was developing as an artificial blood and stopped development) containing creams are on the market. These are based on the same idea as above. But it is doubtful if the oxygen concentration in skin tissue can be increased by this method.

2. Mechanism of action for tissue oxygen increase by carbon dioxide

A. Hemoglobin carries oxygen.

Metabolism activation of skin cell by eCO2GEL uses the oxygen which erythrocyte carries. Oxygen dissolves into water and blood a little. This is called "physical dissolution". Only about 6.5ml of oxygen dissolves into 1L of water at the water temperature of 20 degrees. The amount of physical dissolutions of oxygen is low, and more oxygen is required for supporting activity of a creature. Therefore, erythrocyte has much oxygen conveyance protein called hemoglobin. There is an iron atom in hemoglobin. Oxygen molecule combines with this iron atom, and changes into oxy-hemoglobin. It carries oxygen through blood. Oxygen intake by erythrocyte like this is called "chemical dissolution". It is said that the chemical dissolution of oxygen is about 70 times greater than the physical dissolution and it turns out that oxygen supply is mainly performed by erythrocyte (hemoglobin). In this case, an iron atom is not oxidized in the bond of oxygen molecule and iron atom, so it is called "oxygen addition" and is distinguished from the usual oxidization. It is said that the volume of an erythrocyte is about 1/5 million of 1 ? (1mm angle), and about 640 million hemoglobin is contained in an erythrocyte.

Iron containing medicine is used for anemia treatment to supply raw material of hemoglobin. It is clear that hemoglobin plays an important role in oxygen conveyance.


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